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References: Obesity puts your life in danger

1. Paolisso G, Tataranni PA, Foley JE, Bogardus C, Howard BV, Ravussin E:high concentration  

   of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM.     Diabetologia 38:1213–1217, 1995

2. Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose fatty-acid cycle: its role in     insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i:785–789,

3. Lillioja S, Bogardus C, Mott D, Kennedy LA, Knowler WC, Howard BV: Relationship between     insulin-mediated glucose disposal and lipid metabolism in man. J Clin Invest 75:1106 –15

4. Ferrannini E, Barrett EJ, Bevilacqua S, De Fronzo RA: Effect of fatty acids on glucose     production and utilization in man. J Clin Invest 72:1737–1747, 1983

5. Waldhausl WK, Roden M: The effects of free fatty acids on glucose transport and     phosphorylation in human skeletal muscle. Curr Opin Endocrinol Diabetes 7:211–216, 2000

6. Bollheimer LC, Skelly RH, Chester MW, McGarry JD, Rhodes CJ: Chronic exposure to free fatty    acid reduces pancreatic b-cell insulin content by increasing basal insulin secretion that is not    compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin    Invest 101:1094 –1101, 1998

7.Zhou Y, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-    induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest    870–876, 1994

8. Zhou Y, Grill VE: Long term exposure to fatty acids and ketones inhibits b-cell functions in    human pancreatic islets of Langerhans. J Clin Endocrinol Metab 80:1584 –1590, 1995

9. Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH: b-Cell lipotoxicity in the     pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in     adipocyte-b-cell relationships. Proc Natl Acad Sci U S A 91:10878 –10882, 1994

References: Conceiving a Baby

1. Impact of obesity on female fertility and fertility treatment Murizah M Zain  Robert J     Norman Women's Health March 2008, Vol. 4, No. 2, Pages 183-194

2. Role of oxidative stress in female reproduction. Agarwal A, Gupta S, Sharma RK. Reprod     Biol Endocrinol. 2005 Jul 14;3:28.

3. Evaluation of the relationship between insulin resistance and recurrent pregnancy loss.    Celik N, Evsen MS, Sak ME, Soydinc E, Gul T. Ginekol Pol. 2011 Apr;82(4):272-5.

4. [Does 5-methyltetrahydrofolate offer any advantage over folic acid?]. Leemans L. J Pharm     Belg. 2012 Dec;(4):16-22.

5. The prevalence of coeliac disease in infertility G.F. Meloni1,4,  S. Dessole2, N. Vargiu2,     P.A. Tomasi3 and S. Musumeci1 Oxford Journals Medicine Human Reproduction Volume 14,     Issue 11 Pp. 2759-2761

6. Alcohol and caffeine consumption and decreased fertility  Rosemarie B Hakim Ronald H    Gray Howard Zacur Fertility and Sterility Volume 70, Issue 4, October 1998, Pages 632–637

7. [Exercise and the male reproductive system].  Eliakim A, Nemet D. Harefuah. 2006     Sep;145(9):677-81, 702, 701.

References: Friendly Sweet

 1.Reappraisal of the role of insulin in hypertriglyceridemia. Olefsky JM, Farquhar JW, Reaven    GM  Am J Med. 1974 Oct;57(4):551-60.

2.[Experiences with fat-free diet in diabetes mellitus]. WOLF HJ, PRIESS H. Dtsch Med    Wochenschr. 1956 Apr 6;81(14):514-5.

3. Response of non-insulin-dependent diabetic patients to an intensive program of diet and     exercise. Barnard RJ, Lattimore L, Holly RG, Cherny S, Pritikin N. Diabetes Care. 1982 Jul-     Aug;5(4):370-4.

4.Potential Efficacy of Broccoli Sprouts as a Unique Supplement for Management of Type 2    Diabetes and Its Complications. Bahadoran Z, Mirmiran P, Azizi F. J Med Food. 2013 Apr 30.

5.Antihyperglycemic, antihyperlipidemic, anti-inflammatory and adenosine deaminase–    lowering effects of garlic in patients with type 2 diabetes mellitus with obesity Rahat    Kumar et al. Diabetes Metab Syndr Obes. 2013; 6: 49–56.

6.Comprehensive Review of Apples and Apple Components and Their Relationship to Human    Health Dianne A.  Hyson Adv Nutr. 2011 September; 2(5): 408–420.

References: An Enemy to Fight

1. Cancer prevention with natural compounds. Gullett NP, Ruhul Amin AR, Bayraktar S,     Pezzuto     JM, Shin DM, Khuri FR, Aggarwal BB, Surh YJ, Kucuk O. Semin oncology 2010     Jun;37(3):258-     81

2. A prospective study of major dietary patterns and the risk of breast cancer. Terry P,     Suzuki R, Hu FB, Wolk A. Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1281-5.

3. Overview of the health benefits of fruit and vegetable consumption for the dietetics     professional: selected literature. Van Duyn MA, Pivonka E. J Am Diet Assoc. 2000     Dec;100(12):1511-21.

4. Inhibition of benzo[a]pyrene-induced mutagenesis by (-)-epigallocatechin gallate in the     lung of rpsL transgenic mice.

5. Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-     methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the     F344 rat. Xu M, Bailey AC, Hernaez JF, Taoka CR, Schut HA, Dashwood RH.     Carcinogenesis. 1996  Jul;17(7):1429-34.

6. Growth factor-dependent induction of p21(CIP1) by the green tea polyphenol,     epigallocatechin gallate. Liberto M, Cobrinik D. Cancer Lett. 2000 Jun 30;154(2):151-61.

7. Chemoprevention of colon cancer by dietary curcumin. Rao CV, Rivenson A, Simi B, Reddy     BS. Ann N Y Acad Sci. 1995 Sep 30;768:201-4..

8. A review of the content of the putative chemopreventive phytoalexin resveratrol .. Ulrik     Stervboa, b, Ole Vanga, Christine Bonnesen Food Chemistry Volume 101, Iss 2,     2007,44957.

9.  Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and    vegetables. Zhang Y, Vareed SK, Nair MG. Life Sci. 11;76(13):1465-72.2004 Dec 13.

10.Downregulation of androgen receptor expression by luteolin causes inhibition of cell     proliferation and induction of apoptosis in human prostate cancer cells and xenografts.

Chiu FL, Lin JK. Prostate. 2008 Jan 1;68(1):61-71. Prostate. 2008 Jan 1;68(1):61-71.

11.Luteolin induces apoptosis in oral squamous cancer cells. Yang SF, Yang WE, Chang HR,     Chu SC, Hsieh YS.  J Dent Res. 2008 Apr;87(4):401-6.

12.Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma      cell line (KYSE-510) by induction of G2/M arrest and apoptosis. Zhang Q, Zhao XH, Wang      ZJ. oxicol In Vitro. 2009 Aug;23(5):797-807. doi: 10.1016/j.tiv.2009.04.007. 2009 May 3.

13.A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis     factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung     cancer  cells. Ju W, Wang X, Shi H, Chen W, Belinsky SA,. Mol Pharmacol. 2007 1381-8.

14.Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the     d     dietary   compound luteolin. Lim do Y, Jeong Y, Tyner AL, Park JH. Am J Physiol     Gastrointest Liver      Physiol. 2007 Jan;292(1):G66-75. Epub 2006 Aug 10.

15.Food and drink around the world. In: Miller N, Wetterstrom W, Roger D, et al. Kiple K,     Ornelas K, editors. The Cambridge World History of Food. Cambridge: Cambridge     University     Press, 2000.

16.Peasant Agriculturalists. In: Trowell H, Sinnett P, Whyte M, Williams E, et al. Burkitt D,     editors. Western Diseases: Their Emergence and Prevention. London: Edward Arnold, 1981

17.Infectious disease: humans and microbes co-evolving. In: McMichael AJ Press CU, editor.     Human Frontiers, Environments and Disease. Past Patterns, Uncertain Futures.     Cambridge, 2001.

References: Get Younger

1. Discovering the link between nutrition and skin aging Silke K. Schagen,  Vasiliki A. Zampeli,  Evgenia Makrantonaki, and Christos C. Zouboulis Dermatoendocrinol. 2012 July 1; 4(3): 298–307.

2. The role of nutraceuticals in anti-aging medicine. Vranesić-Bender D. Acta Clin Croat. 2010 Dec;49(4):537-44.

3. Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults. Arch Biochem Scarmo S, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, et al. Biophys 2010; 504:34-9.

4. Antihypertensive potential and mechanism of action of astaxanthin: III. Antioxidant and histopathological effects in spontaneously hypertensive rats. Hussein G, Goto H, Oda S, Sankawa U, Matsumoto K, Watanabe H.Biol Pharm Bull 2006; 29:684-    

5. Potential healthpromoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Yuan JP, Peng J, Yin K, Wang JH. Mol Nutr Food Res 2011; 55:150-65;

6. Astaxanthin: a review of its chemistry and applications. Higuera-Ciapara I, Félix-Valenzuela L, Goycoolea FM.  Crit Rev Food Sci Nutr 2006; 46:185-96;

7. Polyphenols: food sources and bioavailability. Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Am J Clin Nutr 2004; 79:727-47

8. Curcumin targeted signaling pathways: basis for anti-photoaging and anti-carcinogenic therapy. Heng MC. Int J Dermatol 2010; 49:608-22;

9. Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Kwong LK, Kamzalov S, Rebrin I, Bayne AC, Jana CK, Morris P, et al Biol Med 2002; 33:627-38.

References: Moody? Run down? Hyper? Stressed out? Make your life easier-     

 1. Mortality of patients with mood disorders: follow-up over 34-38 years. Angst F, Stassen HH, Clayton PJ, Angst J. J Affect Disord. 2002 Apr;68(2-3):167-81.                  

 2. Nutrition and depression at the forefront of progress TA Popa* and M Ladea J Med Life. 2012 December 15; 5(4): 414–419.                                                                          

3. Dietary pattern and depressive symptoms in middle age. Br J Psychiatry Akbaraly T, Brunner E.. 2009;195:408–413.

  4. Vitamin D and the Occurrence of Depression: Causal Association or Circumstantial Evidence? Elizabeth R. Bertone-Johnson, ScD Nutr Rev.2009 August ; 67(8): 481–492.

 References: Food Allergies

1. Inflammation and gastrointestinal cancer: an overview. Marusawa H, Jenkins BJ. Cancer  Lett. 2013 Aug 24.

2. Alternative Medicine, the definitive guide.                                                

3. Clinical Allergy, diagnosis and management, Gerald Volcheck.

References: Heads or Tails: a Journey into the Health Benefits of Alcohol

1. Effects of moderate alcohol consumption on cognitive function in women. Stampfer MJ1, Kang JH, Chen J, Cherry R, Grodstein F. N Engl J Med. 2005:245-53.

2. Phenolic acid intake, delivered via moderate champagne wine consumption, improves     spatial working memory via the modulation of hippocampal and cortical protein     expression/activation.Corona G1, Vauzour D, Hercelin J, Wilams CM, Spencer JP. Antioxid Redox Signal. 2013     Nov 10;19(14):1676-89. doi: 10.1089/ars.2012.514

3. Metabolism of antioxidant and chemopreventive ellagitannins from strawberries,     raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and     individual variability.  Cerdá B1, Tomás-Barberán FA, Espín JC. J Agric Food Chem. 2005 Jan 26;53(2):227-35.